TY  - JOUR
TI  - Morphological changes in kidneys and clinical presentation in patients with primary and secondary membranous nephropathy
AU  - Milivojević, Danijel
AU  - Pecić, Maja
AU  - Nikolić, Gorana
AU  - Mioljević, Ana
AU  - Brković, Voin
AU  - Baralić, Marko
AU  - Đurić, Petar
AU  - Janković, Aleksandar
AU  - Radojević-Škodrić, Sanja
AU  - Životić, Maja
T2  - Serbian Journal of the Medical Chamber
AB  - Introduction/Aim: Membranous nephropathy (MN) typically presents as nephrotic syndrome and may be idiopathic (primary MN, pMN) or occur secondary to other diseases (secondary MN, sMN). Given the differing therapeutic approaches, this study aimed to compare clinical and pathohistological parameters between patients with pMN and sMN. Methods: Through a retrospective analysis of kidney biopsy samples diagnosed at the Institute of Pathology, Faculty of Medicine, Belgrade, between 2011 and 2023, 99 patients with membranous nephropathy were identified. These patients were divided into two groups: patients with pMN (n = 44) and patients with sMN (n = 55). Clinical and pathohistological parameters (by optical and immunofluorescence microscopy) were compared among study participants. Results: While males more frequently suffered from MN, females more frequently had sMN (p = 0.036). Haematuria was more common in subjects with sMN (p = 0.009). Proteinuria values were significantly higher among patients with pMN (p = 0.018), related to a significantly greater decrease in serum total protein values in them (p = 0.011). Endocapillary proliferation was significantly more frequent among those with sMN (p = 0.032). Marked positivity of several immunofluorescent markers was significantly more common in subjects with sMN: IgA, IgM, C1q, κ-chains, and λ-chains (p < 0.05). Conclusion: Females are more commonly affected by sMN. Characteristics of sMN include presence of haematuria, endocapillary hypercellularity and mmunofluorescence positivity for markers not seen in pMN (IgA, IgM, C1q), while characteristics of pMN include significantly higher levels of proteinuria, accompanied by significantly reduced serum protein values.
DA  - 2025///
PY  - 2025
DO  - 10.5937/smclk6-62894
VL  - 6
IS  - 4
SP  - 363
EP  - 372
SN  - 2737-9752
UR  - https://www.smj.rs/en/volume-6-no-4/morphological-changes-in-kidneys-and-clinical-presentation-in-patients-with-primary-and-secondary-membranous-nephropathy
ER  -